Mistranslation can enhance fitness through purging of deleterious mutations?

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In addition, mistranslation could benefit adaptive evolution by exacerbating deleterious effects of mutationsā€¦ This advantage is associated with increased purging of deleterious mutations, which can increase mean population fitness.

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Here, the authors show that mistranslation can increase the response to directional selection by exacerbating the fitness effects of deleterious DNA mutations. Phenotypic mutations are amino acid...

antibiotic resistance phenotype, mistranslation can lead to purging of weakly deleterious mutations, which can increase mean population ļ¬tness. Under stabilizing selection, mistransla-tion may decrease mistranslation rates or increase robustness to mistranslation5,11,28. How the effects of mistranslation interact

In sum, we showed that under directional selection for a new antibiotic resistance phenotype, mistranslation can lead to purging of weakly deleterious mutations, which can increase mean population fitness. Under stabilizing selection, mistranslation may decrease mistranslation rates or increase robustness to mistranslation 5,11,28.

Our observations show that mistranslation is not just a source of noise that delays adaptive evolution. It could even facilitate adaptive evolution by exacerbating the effects of deleterious mutations and leading to their more efficient purging.

Phenotypic mutations are amino acid changes caused by mistranslation. How phenotypic mutations affect the adaptive evolution of new protein functions is unknown. Here we evolve the antibiotic resistance protein TEM-1 towards resistance on the antibiotic cefotaxime in an Escherichia coli strain with a high mistranslation rate. TEM-1 populations evolved in such strains endow host cells with a ...

Mistranslation can enhance fitness through purging of deleterious mutations @article{Bratuli2017MistranslationCE, title={Mistranslation can enhance fitness through purging of deleterious mutations}, author={Sini{\vs}a Bratuli{\'c} and M. Toll-Riera and A. Wagner}, journal={Nature Communications}, year={2017}, volume={8} }

Sigma-Aldrich offers abstracts and full-text articles by [Sinisa Bratulic, Macarena Toll-Riera, Andreas Wagner].

Mistranslation can enhance fitness through purging of deleterious mutations . By Sinisa Bratulic, Macarena Toll-Riera and Andreas Wagner. Cite . BibTex; Full citation; Publisher: Springer Nature. Year: 2017. DOI identifier: 10.1038/ncomms15410. OAI identifier: Provided by: MUCC ...

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In addition, mistranslation could benefit adaptive evolution by exacerbating deleterious effects of mutations. As mistranslation increases the efficiency of purifying selection 11, it may help...

Mistranslation can enhance fitness through purging of deleterious mutations. Bratulic S (1) (2), Toll-Riera M (1) (2), Wagner A (1) (2) (3).

Mistranslation can enhance ļ¬tness through purging of deleterious mutations Sinisa Bratulic1,2, Macarena Toll-Riera1,2 & Andreas Wagner1,2,3 Phenotypic mutations are amino acid changes caused by mistranslation. How phenotypic mutations affect the adaptive evolution of new protein functions is unknown. Here we evolve the antibiotic resistance protein TEM-1 towards resistance on the antibiotic cefotaxime in an Escherichia coli strain with a high mistranslation rate. TEM-1 populations evolved ...

Mistranslation can enhance fitness through purging of deleterious mutations. Nat. Commun. 8, 15410 doi: 10.1038/ncomms15410 (2017). Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

purging of deleterious mutations Sinisa Bratulic 1,2 , Macarena T oll-Riera 1,2 & Andreas W agner 1,2,3 Phenotypic mutations are amino acid changes caused by mistranslation.

It could even facilitate adaptive evolution by exacerbating the effects of deleterious mutations and leading to their more efficient purging. The ubiquity of mistranslation and its effects render mistranslation an important factor in adaptive protein evolution. Phenotypic mutations are amino acid changes caused by mistranslation. How phenotypic mutations affect the adaptive evolution of new protein functions is unknown. Here we evolve the antibiotic resistance protein TEM-1 towards ...

Mistranslation can enhance fitness through purging of deleterious mutations. (PMID:28524864 PMCID:PMC5454534) ... -throughput sequencing of TEM-1 populations shows that this advantage is associated with a lower incidence of weakly deleterious genotypic mutations. Our observations show that mistranslation is not just a source of noise that delays adaptive evolution. It could even facilitate adaptive evolution by exacerbating the effects of deleterious mutations and leading to their more ...

Mistranslation can enhance fitness through purging of deleterious mutations. Bratulic S, Toll-Riera M, Wagner A. Nat Commun, 8:15410, 19 May 2017 Cited by: 10 articles | PMID: 28524864 | PMCID: PMC5454534. Free to read & use

Mistranslation can enhance fitness through purging of deleterious mutations By Sinisa Bratulic, Macarena Toll-Riera and Andreas Wagner Get PDF (583 KB)

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